For research use only. Not for therapeutic Use.
NCGC00378430（Cat No.:I044581）is a small-molecule inhibitor identified as a potent antagonist of the NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing) signaling pathways. These intracellular pattern recognition receptors play key roles in innate immunity by detecting bacterial peptidoglycans and activating NF-κB-mediated inflammatory responses. NCGC00378430 effectively blocks NOD1/2-induced signaling, reducing the production of pro-inflammatory cytokines such as IL-8. It is valuable for research into inflammatory and autoimmune diseases, including Crohn’s disease and rheumatoid arthritis. This compound serves as a useful tool for dissecting NOD pathway mechanisms and exploring therapeutic interventions targeting innate immune dysregulation.
| CAS Number | 920650-00-6 |
| Synonyms | N-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)-3-pyrrol-1-ylbenzamide |
| Molecular Formula | C22H23N3O5S |
| Purity | ≥95% |
| IUPAC Name | N-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)-3-pyrrol-1-ylbenzamide |
| InChI | InChI=1S/C22H23N3O5S/c1-29-20-8-7-18(16-21(20)31(27,28)25-11-13-30-14-12-25)23-22(26)17-5-4-6-19(15-17)24-9-2-3-10-24/h2-10,15-16H,11-14H2,1H3,(H,23,26) |
| InChIKey | IFXCVBOQNYHBMX-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N3C=CC=C3)S(=O)(=O)N4CCOCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
