For research use only. Not for therapeutic Use.
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].
| Catalog Number | I012370 |
| CAS Number | 65974-52-9 |
| Synonyms | dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate |
| Molecular Formula | C12H11NO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H11NO6/c1-18-11(14)9(12(15)19-2)7-8-5-3-4-6-10(8)13(16)17/h3-7H,1-2H3 |
| InChIKey | LKLMASCOTOBEMT-UHFFFAOYSA-N |
| SMILES | COC(=O)C(=CC1=CC=CC=C1[N+](=O)[O-])C(=O)OC |
| Reference | [1]. Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9. |
