NCI126224

• CAT Number: I012370
• CAS Number: 65974-52-9
• Molecular Formula: C12H11NO6
• Molecular Weight: 265.22
• Purity: ≥95%
• Synonyms: dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate
• InChI: InChI=1S/C12H11NO6/c1-18-11(14)9(12(15)19-2)7-8-5-3-4-6-10(8)13(16)17/h3-7H,1-2H3
• InChIKey: LKLMASCOTOBEMT-UHFFFAOYSA-N
• SMILES: COC(=O)C(=CC1=CC=CC=C1[N+](=O)[O-])C(=O)OC

NCI126224 (Cat No.: I012370) is a small-molecule compound identified through the National Cancer Institute’s drug screening program for its potential anticancer properties. It exhibits activity against certain cancer cell lines, suggesting it may interfere with key molecular pathways involved in tumor growth and survival. While its exact mechanism of action is still under investigation, NCI126224 is believed to impact processes such as cell cycle regulation or apoptosis. Further studies are focused on exploring its efficacy, optimizing its formulation, and evaluating its potential in clinical oncology applications.

Reference

[1]. Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9.
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