For research use only. Not for therapeutic Use.
NCL-00017509 is a potent kinase-selective irreversible Nek2 inhibitor (IC50 value of 56 nM) with promising drug-like properties.
KEYWORDS: NCL-00017509 | supplier | Nek2 Inhibitor | NCL00017509 | NCL 00017509 | CAS [1507367-00-1] | C-Nap1 | PP1 | Nek2 | Nek | Inhibitor | Enzymes
| Catalog Number | I011117 |
| CAS Number | 1507367-00-1 |
| Molecular Formula | C15H12N6O |
| Purity | ≥95% |
| IUPAC Name | 2-[3-[(6-ethynyl-7H-purin-2-yl)amino]phenyl]acetamide |
| InChI | InChI=1S/C15H12N6O/c1-2-11-13-14(18-8-17-13)21-15(20-11)19-10-5-3-4-9(6-10)7-12(16)22/h1,3-6,8H,7H2,(H2,16,22)(H2,17,18,19,20,21) |
| SMILES | C#CC1=C2C(=NC(=N1)NC3=CC=CC(=C3)CC(=O)N)N=CN2 |
| Reference | B Carbain et al. 118 2-arylamino-6-ethynylpurines as Potent Irreversible Inhibitors of the Mitotic Kinase Nek2. Eur J Cancer 2012; 48, Supplement 6:37.
H Lebraud et al. Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org Biomol Chem. 2014 Jan 7;12(1):141-8. |
