For research use only. Not for therapeutic Use.
NCRW0005-F05 is a potent GPR139 antagonist with an IC50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson’s disease[1].
| Catalog Number | I042951 |
| CAS Number | 342779-66-2 |
| Synonyms | 3,3-difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-one |
| Molecular Formula | C16H13F2NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H13F2NO2/c1-21-13-9-7-11(8-10-13)14-16(17,18)15(20)19(14)12-5-3-2-4-6-12/h2-10,14H,1H3 |
| InChIKey | AIIIYUSGINMZMS-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2C(C(=O)N2C3=CC=CC=C3)(F)F |
| Reference | [1]. Wang J, et al. High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139. Acta Pharmacol Sin. 2015 Jul;36(7):874-8. |
