NCT-503

• CAT Number: I008258
• CAS Number: 1916571-90-8
• Molecular Formula: C20H23F3N4S
• Molecular Weight: 408.50
• Purity: ≥95%
• Synonyms: NCT-503; NCT 503; NCT503.;N-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide
• Target: Phosphoglycerate Dehydrogenase (PHGDH)
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IC50: 2.5 µM
• IUPAC Name: N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
• InChI: InChI=1S/C20H23F3N4S/c1-14-11-15(2)24-18(12-14)25-19(28)27-9-7-26(8-10-27)13-16-3-5-17(6-4-16)20(21,22)23/h3-6,11-12H,7-10,13H2,1-2H3,(H,24,25,28)
• InChIKey: PJNSZIQUFLWRLH-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F)C

NCT-503（Cat No.:I008258）is a potent and selective inhibitor of phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthesis pathway. By targeting PHGDH, NCT-503 effectively reduces serine production, disrupting cellular proliferation, particularly in cancer cells reliant on this pathway for growth. This makes NCT-503 a valuable compound in cancer research, especially for studying tumors with upregulated serine biosynthesis, such as certain breast cancers. Its ability to selectively inhibit PHGDH provides insights into targeting metabolic vulnerabilities in cancer, offering potential for the development of novel therapeutic strategies.