For research use only. Not for therapeutic Use.
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].
ND-011992 inhibits NADH oxidase activity of membranes from bovine heart mitochondria with an IC50 of 3.27 µM[1].
| Catalog Number | I040783 |
| CAS Number | 2446880-46-0 |
| Synonyms | N-[4-[4-(trifluoromethyl)phenoxy]phenyl]quinazolin-4-amine |
| Molecular Formula | C21H14F3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C21H14F3N3O/c22-21(23,24)14-5-9-16(10-6-14)28-17-11-7-15(8-12-17)27-20-18-3-1-2-4-19(18)25-13-26-20/h1-13H,(H,25,26,27) |
| InChIKey | CAIODVXPWNFDFE-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F |
| Reference | [1]. Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w |
