For research use only. Not for therapeutic Use.
ND-011992(CAT: I040783) is a reversible, selective quinazoline-type inhibitor that targets key enzymes involved in bacterial respiration, including quinone reductases and quinol oxidases. It effectively inhibits respiratory complex I and cytochrome bo₃ oxidase, as well as bd-I and bd-II oxidases in E. coli strain BL21*Δcyo, with IC₅₀ values of 0.12 μM, 2.47 μM, 0.63 μM, and 1.3 μM, respectively. By impairing multiple respiratory pathways, ND-011992 disrupts bacterial energy metabolism, making it a valuable tool for studying Mycobacterium tuberculosis and exploring new therapeutic strategies against tuberculosis and antibiotic-resistant bacterial infections.
| CAS Number | 2446880-46-0 |
| Synonyms | N-[4-[4-(trifluoromethyl)phenoxy]phenyl]quinazolin-4-amine |
| Molecular Formula | C21H14F3N3O |
| Purity | ≥95% |
| IUPAC Name | N-[4-[4-(trifluoromethyl)phenoxy]phenyl]quinazolin-4-amine |
| InChI | InChI=1S/C21H14F3N3O/c22-21(23,24)14-5-9-16(10-6-14)28-17-11-7-15(8-12-17)27-20-18-3-1-2-4-19(18)25-13-26-20/h1-13H,(H,25,26,27) |
| InChIKey | CAIODVXPWNFDFE-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
