For research use only. Not for therapeutic Use.
NDGA (Nordihydroguaiaretic acid)（Cat No.:I003757）is a natural antioxidant derived from the creosote bush, known for its potent anti-inflammatory and anti-cancer properties. As a lipoxygenase inhibitor, NDGA blocks the formation of leukotrienes, which are involved in inflammatory responses, making it valuable in studying inflammation-related conditions like arthritis and asthma. Additionally, NDGA has shown potential in cancer research due to its ability to inhibit cell proliferation and induce apoptosis. Its diverse biological activities make NDGA a useful compound in exploring treatments for chronic diseases and cancer.
| Catalog Number | I003757 |
| CAS Number | 500-38-9 |
| Synonyms | 4,4/’-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) |
| Molecular Formula | C₁₈H₂₂O₄ |
| Purity | ≥95% |
| Target | mTOR |
| Solubility | DMSO: 43 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
| InChI | InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 |
| InChIKey | HCZKYJDFEPMADG-UHFFFAOYSA-N |
| SMILES | CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O |
| Reference | </br>1:Antiviral activity of nordihydroguaiaretic acid and its derivative tetra-O-methyl nordihydroguaiaretic acid against West Nile virus and Zika virus. Merino-Ramos T, Jiménez de Oya N, Saiz JC, Martín-Acebes MA.Antimicrob Agents Chemother. 2017 May 15. pii: AAC.00376-17. doi: 10.1128/AAC.00376-17. [Epub ahead of print] PMID: 28507114 </br>2:NDGA-P21, a novel derivative of nordihydroguaiaretic acid, inhibits glioma cell proliferation and stemness. Zhao QW, Lin Y, Xu CR, Yao YL, Cui YH, Zhang X, Bian XW.Lab Invest. 2017 May 15. doi: 10.1038/labinvest.2017.46. [Epub ahead of print] PMID: 28504686 </br>3:Protective effect of nordihydroguaiaretic acid (NDGA) on the transgenic Drosophila model of Alzheimer/’s disease. Siddique YH, Ali F.Chem Biol Interact. 2017 May 1;269:59-66. doi: 10.1016/j.cbi.2017.04.005. Epub 2017 Apr 6. No abstract available. PMID: 28392391 </br>4:Long chain polyunsaturated fatty acids (LCPUFAs) and nordihydroguaiaretic acid (NDGA) modulate metabolic and inflammatory markers in a spontaneous type 2 diabetes mellitus model (Stillman Salgado rats). Dain A, Repossi G, Diaz-Gerevini GT, Vanamala J, Das UN, Eynard AR.Lipids Health Dis. 2016 Nov 25;15(1):205. PMID: 27884155 Free PMC Article</br>5:Nordihydroguaiaretic acid impairs prostate cancer cell migration and tumor metastasis by suppressing neuropilin 1. Li X, Fan S, Pan X, Xiaokaiti Y, Duan J, Shi Y, Pan Y, Tie L, Wang X, Li Y, Li X.Oncotarget. 2016 Dec 27;7(52):86225-86238. doi: 10.18632/oncotarget.13368. PMID: 27863391 Free PMC Article</br>6:Repositioning nordihydroguaiaretic acid as a potent inhibitor of systemic amyloidosis and associated cellular toxicity. Nusrat S, Zaidi N, Zaman M, Islam S, Ajmal MR, Siddiqi MK, Santra MK, Khan RH.Arch Biochem Biophys. 2016 Dec 15;612:78-90. doi: 10.1016/j.abb.2016.10.014. Epub 2016 Oct 24. PMID: 27789205 </br>7:Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs. Bergren DR, Valentine JL.Respir Physiol Neurobiol. 2016 Dec;234:26-31. doi: 10.1016/j.resp.2016.09.003. Epub 2016 Sep 3. PMID: 27595978 </br>8:Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines. Leon D, Parada D, Vargas-Uribe M, Perez AA, Ojeda L, Zambrano A, Reyes AM, Salas M.FEBS Open Bio. 2016 Aug 23;6(10):1000-1007. eCollection 2016 Oct. PMID: 27761359 Free PMC Article</br>9:Correction: A Comprehensive Spectroscopic and Computational Investigation to Probe the Interaction of Antineoplastic Drug Nordihydroguaiaretic Acid with Serum Albumins. Nusrat S, Siddiqi MK, Zaman M, Zaidi N, Ajmal MR, Alam P, Qadeer A, Abdelhameed AS, Khan RH.PLoS One. 2016 Oct 13;11(10):e0164927. doi: 10.1371/journal.pone.0164927. eCollection 2016. PMID: 27736985 Free PMC Article</br>10:A Comprehensive Spectroscopic and Computational Investigation to Probe the Interaction of Antineoplastic Drug Nordihydroguaiaretic Acid with Serum Albumins. Nusrat S, Siddiqi MK, Zaman M, Zaidi N, Ajmal MR, Alam P, Qadeer A, Abdelhameed AS, Khan RH.PLoS One. 2016 Jul 8;11(7):e0158833. doi: 10.1371/journal.pone.0158833. eCollection 2016. Erratum in: PLoS One. 2016 Oct 13;11(10 ):e0164927. PMID: 27391941 Free PMC Article |
