NE10575

• CAT Number: I008019
• CAS Number: 154618-13-0
• Molecular Formula: (a)C6H8O7(anhydrous)
• Molecular Weight: 192.12
• Purity: ≥95%
• Synonyms: NE10575; NE 10575; NE-10575.;3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridin-1-ium
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2-hydroxypropane-1,2,3-tricarboxylic acid
• InChI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• InChIKey: KRKNYBCHXYNGOX-UHFFFAOYSA-N
• SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O

NE10575 (Cat No.: I008019) is a synthetic peptide-based inhibitor targeting the complement component C5, preventing its cleavage into C5a and C5b. By blocking C5 activation, NE10575 inhibits the formation of the membrane attack complex (MAC) and reduces inflammatory responses mediated by C5a. It is widely used in immunology research to study complement-related diseases, including autoimmune disorders, sepsis, and inflammatory conditions. As a complement pathway inhibitor, NE10575 holds potential for therapeutic applications in conditions where excessive complement activation contributes to disease progression.