Neamine

• CAT Number: R031176
• CAS Number: 3947-65-7
• Molecular Formula: C12H26N4O6
• Molecular Weight: 322.36
• Purity: ≥95%
• Synonyms: 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine; Neamine; Nebramycin X; Negamicin; O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-1,3-diamino-1,2,3-trideoxy-D-myo-inositol; ST 7; Dekamycin V
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxyoxane-3,4-diol
• InChI: InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1
• InChIKey: SYJXFKPQNSDJLI-HKEUSBCWSA-N
• SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)O)O)N

Neamine（Cat No.:R031176）is an aminoglycoside antibiotic derived from neomycin, known for its antibacterial properties, especially against gram-positive and some gram-negative bacteria. It functions by binding to the bacterial ribosome, disrupting protein synthesis and ultimately causing bacterial cell death. While its use as a standalone antibiotic is limited, Neamine serves an important role in research due to its unique structural properties and reduced toxicity compared to other aminoglycosides. It is often studied for its potential in drug design, particularly in modifying aminoglycosides to reduce toxicity while retaining antimicrobial efficacy.

Reference

Macdonald, R. H., and M. Beck. /Neomycin: A Review with Particular Reference to Dermatological Usage./ Department of Dermatology 8 (1982): 249-58. Onlinelibrary.com. Web. 16 July 2013. Tsuji, Kiyoshi, and John H. Robertson. /Comparative Study of Responses to Neomycins B and C by Microbiological and Gas-Liquid Chromatographic Assay Methods./Applied Microbiology 18.3 (1969): 396-98. Nih.gov. Web. 23 Oct. 2013. Yuan, LingLing, and HongPing Wei. /Rapid Analysis of Native Neomycin Components on a Portable Capillary Electrophoresis System with Potential Gradient Detection./Analytical and Bioanalytical Chemistry 385.8 (2006): 1575-579. Nih.gov. Web. 23 Oct. 2013. Robertson, John H. /Antimicrobial Activity of Neomycin C Against Staphylococcus Epidermidis./ Applied Microbiology 22.6 (1971): 1164-165. Nih.gov. Web. 23 Oct. 2013.