Nebivolol

• CAT Number: C000725
• CAS Number: 99200-09-6
• Molecular Formula: C₂₂H₂₅F₂NO₄
• Molecular Weight: 405.44
• Purity: ≥95%
• Synonyms: α,α’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• Target: Neuronal Signaling
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• Appearance: White to Off-White Solid
• Storage: 2-8°C(protect from light)
• IUPAC Name: 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
• InChI: InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
• InChIKey: KOHIRBRYDXPAMZ-UHFFFAOYSA-N
• SMILES: C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O

Nebivolol (Cat No.:C000725) is a cardiovascular medication belonging to the class of beta-blockers. It is primarily used to treat hypertension (high blood pressure) and heart failure. Nebivolol works by blocking beta-adrenergic receptors, leading to decreased heart rate and reduced cardiac output, resulting in lowered blood pressure and improved heart function. Notably, it also has vasodilatory properties due to its ability to increase the production of nitric oxide. Nebivolol’s unique mechanism and vasodilating effects make it a valuable therapeutic option for managing cardiovascular conditions, offering benefits beyond traditional beta-blockers.

Reference

Montoya, A., et al.: Oncotarget, 8, 6446-6460 (2017);