(-)-Nebivolol-d4 Hydrochloride

• CAT Number: R049989
• CAS Number: NA
• Molecular Formula: C₂₂H₂₂D₄ClF₂NO₄
• Molecular Weight: 445.92
• Purity: ≥95%
• Synonyms: (αS,α’S,2R,2’S)-α,α’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]-d4 Hydrochloride; [2S-[2R*[R*[R*(S*)]]]]-α,α’-[Iminobis?(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol-d4 Hydrochloride; R-67145-d4 Hydroc
• Storage: -20°C
• IUPAC Name: (1S)-2,2-dideuterio-2-[[(2S)-1,1-dideuterio-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol;hydrochloride
• InChI: InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1/i11D2,12D2
• InChIKey: JWEXHQAEWHKGCW-YNYGMEKVSA-N
• SMILES: [2H]C([2H])([C@@H]([C@H]1CCC2=C(O1)C=CC(=C2)F)O)NC([2H])([2H])[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O.Cl

(-)-Nebivolol-d4 Hydrochloride is a deuterated form of the enantiomer (-)-nebivolol, where four hydrogen atoms are replaced with deuterium. This isotopically labeled compound is used in pharmaceutical research to study the metabolism, pharmacokinetics, and pharmacodynamics of nebivolol, a beta-blocker commonly used to treat hypertension and heart failure. The deuterium labeling allows for precise tracking in analytical techniques such as mass spectrometry, providing enhanced accuracy and stability in monitoring the drug’s behavior within biological systems. (-)-Nebivolol-d4 Hydrochloride is valuable for researchers aiming to optimize cardiovascular therapies, investigate drug interactions, and better understand the metabolic pathways of nebivolol, aiding in the development of safer and more effective treatments for cardiovascular diseases.