Nec-1s

• CAT Number: I005116
• CAS Number: 852391-15-2
• Molecular Formula: C₁₃H₁₂ClN₃O₂
• Molecular Weight: 277.71
• Purity: ≥95%
• Synonyms: Necrostatin 1s; Nec-1s; 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
• Target: RIP kinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 50 nM (EC50)
• IUPAC Name: 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
• InChI: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
• InChIKey: WIKGAEMMNQTUGL-UHFFFAOYSA-N
• SMILES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl

Nec-1s (CAT: I005116) is a potent and selective inhibitor of necroptosis, a regulated form of cell death that plays a role in various pathological conditions. Nec-1s precisely target and inhibits receptor-interacting protein kinase 1 (RIPK1), a key regulator of necroptosis signaling. By blocking RIPK1 activity, Nec-1s prevent the formation of the necrosome complex and subsequent cell death. This compound has demonstrated efficacy in several disease models associated with necroptosis, including neurodegenerative disorders, ischemic injury, and inflammatory diseases. Nec-1s represents a valuable tool for studying the molecular mechanisms of necroptosis and has potential therapeutic applications in conditions where necroptosis contributes to tissue damage.