For research use only. Not for therapeutic Use.
Necitumumab(CAT: I040742) is a fully human IgG1 monoclonal antibody that targets the epidermal growth factor receptor (EGFR), a key driver in the growth and survival of various cancer cells. By binding specifically to the extracellular domain of EGFR, Necitumumab blocks ligand-induced activation and downstream signaling pathways such as RAS-RAF-MEK-ERK and PI3K-AKT. This inhibition suppresses tumor cell proliferation, angiogenesis, and survival. Approved for the treatment of metastatic squamous non-small cell lung cancer (NSCLC) in combination with chemotherapy, Necitumumab is a valuable therapeutic and research tool in oncology. It is also used in studies exploring EGFR-targeted treatment strategies and resistance mechanisms.
| CAS Number | 906805-06-9 |
| Purity | ≥95% |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
