Necroptosis-IN-1

• CAT Number: I044512
• CAS Number: 1391980-92-9
• Molecular Formula: C12H10ClN3O2
• Molecular Weight: 263.68
• Purity: ≥95%
• Synonyms: 5-[(7-chloro-1H-indol-3-yl)methyl]imidazolidine-2,4-dione
• InChI: InChI=1S/C12H10ClN3O2/c13-8-3-1-2-7-6(5-14-10(7)8)4-9-11(17)16-12(18)15-9/h1-3,5,9,14H,4H2,(H2,15,16,17,18)
• InChIKey: HAPHEBPGIQHYHN-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)Cl)NC=C2CC3C(=O)NC(=O)N3

Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor[1].

Reference

[1]. Jenny L Maki, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427(2):164-74.
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