Necroptosis-IN-3

• CAT Number: I042468
• CAS Number: 547698-18-0
• Molecular Formula: C12H17NOS
• Molecular Weight: 223.33
• Purity: ≥95%
• Synonyms: N-(thiophen-2-ylmethyl)cyclohexanecarboxamide
• InChI: InChI=1S/C12H17NOS/c14-12(10-5-2-1-3-6-10)13-9-11-7-4-8-15-11/h4,7-8,10H,1-3,5-6,9H2,(H,13,14)
• InChIKey: QTYJPNRSYXQPSF-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)C(=O)NCC2=CC=CS2

Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].
TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) inhibits TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells[1].

Reference

[1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.

[2]. Nigel Vicker, et al. Compound. Patent US20100120789A1.