Necrostatin 2 S enantiomer

• CAT Number: I005118
• CAS Number: 852391-20-9
• Molecular Formula: C13H12ClN3O2
• Molecular Weight: 277.71
• Purity: ≥95%
• Synonyms: (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
• Target: RIP kinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 50 nM (EC50) [1]
• IUPAC Name: (5S)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
• InChI: 1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m0/s1
• InChIKey: WIKGAEMMNQTUGL-JTQLQIEISA-N
• SMILES: CN1C(=O)[C@@H](NC1=O)CC2=CNC3=C2C=CC=C3Cl

Necrostatin 2, the S enantiomer(CAT: I005118) is a potent inhibitor of necroptosis with an EC50 of 50 nM. It specifically targets TNF-alpha, a cytokine involved in inflammation and cell death processes. Necrostatin 2 and its derivatives have shown efficacy in inhibiting necroptosis both in vitro and in animal models of ischemic stroke. Necroptosis is a caspase-independent cell death mechanism that resembles necrosis in terms of morphological features. The discovery of necrostatin has provided valuable tools for researchers studying necroptosis and its involvement in various pathological conditions.