For research use only. Not for therapeutic Use.
Necrostatin 2, the S enantiomer(CAT: I005118) is a potent inhibitor of necroptosis with an EC50 of 50 nM. It specifically targets TNF-alpha, a cytokine involved in inflammation and cell death processes. Necrostatin 2 and its derivatives have shown efficacy in inhibiting necroptosis both in vitro and in animal models of ischemic stroke. Necroptosis is a caspase-independent cell death mechanism that resembles necrosis in terms of morphological features. The discovery of necrostatin has provided valuable tools for researchers studying necroptosis and its involvement in various pathological conditions.
Catalog Number | I005118 |
CAS Number | 852391-20-9 |
Synonyms | (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione |
Molecular Formula | C13H12ClN3O2 |
Purity | ≥95% |
Target | RIP kinase |
Solubility | 10 mM in DMSO |
Storage | Store at -20°C |
IC50 | 50 nM (EC50) [1] |
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