For research use only. Not for therapeutic Use.
Necroptosis (Cat.No:R046918) is a regulated caspase-<wbr></wbr>independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-<wbr></wbr>associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-<wbr></wbr>α (TNF-<wbr></wbr>α) induced necrosis. Necrostatin-<wbr></wbr>5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-<wbr></wbr>α-<wbr></wbr>treated FADD-<wbr></wbr>deficient Jurkat cells with an EC<sub>50</sub> value of 240 nM.
| Catalog Number | R046918 |
| CAS Number | 337349-54-9 |
| Synonyms | Nec-5 |
| Molecular Formula | C19H17N3O2S2 |
| Purity | ≥95% |
| Target | Necroptosis |
| Storage | -20°C |
| IUPAC Name | 2-[[3-(4-methoxyphenyl)-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetonitrile |
| InChI | InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3 |
| InChIKey | VGONMECBFMCKBS-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4 |
| Reference | 1.Teng, X.,Degterev, A.,Jagtap, P., et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg. Med. Chem. Lett. 15(22), 5039-5044 (2005). |
