Necrosulfonamide-d4

• CAT Number: S000412
• CAS Number: 1795144-22-7
• Molecular Formula: C18H11D4N5O6S2
• Molecular Weight: 465.50
• Purity: ≥95%
• Target: Mixed Lineage Kinase
• IUPAC Name: (E)-3-(5-nitrothiophen-2-yl)-N-[2,3,5,6-tetradeuterio-4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]prop-2-enamide
• InChI: InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+/i2D,3D,6D,7D
• InChIKey: FNPPHVLYVGMZMZ-GTQWLDGCSA-N
• SMILES: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]

Necrosulfonamide-d4（Cat No.:S000412） is a deuterated version of necrosulfonamide, where four hydrogen atoms are replaced with deuterium. This modification is used to enhance the compound’s stability for more precise pharmacokinetic and biochemical studies. Necrosulfonamide is a chemical compound known for its ability to inhibit the necroptosis pathway, a form of programmed cell death distinct from apoptosis. It specifically targets and blocks the protein MLKL, which is crucial in the execution phase of necroptosis. The deuterated version, Necrosulfonamide-d4, allows researchers to explore the drug’s mechanism of action and pharmacodynamics with improved accuracy in experimental settings.