For research use only. Not for therapeutic Use.
Nedocromil (Cat.No:I004597) is a medication primarily used for the treatment of asthma. It belongs to the class of medications known as mast cell stabilizers, which work by preventing the release of inflammatory substances in the airways. Nedocromil helps to reduce symptoms such as wheezing, shortness of breath, and coughing in individuals with asthma. It is available in various forms, including inhalers and eye drops.
| Catalog Number | I004597 |
| CAS Number | 69049-73-6 |
| Molecular Formula | C19H17NO7 |
| Purity | ≥95% |
| Target | Cysteinyl Leukotriene Receptor(CYSLTR) |
| Solubility | DMSO: ≥ 15 mg/mL |
| Storage | Store at -20°C |
| InChI | InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) |
| InChIKey | RQTOOFIXOKYGAN-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O |
| Reference | </br>1:The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ.Int Immunopharmacol. 2016 Mar;32:87-95. doi: 10.1016/j.intimp.2016.01.003. Epub 2016 Jan 21. PMID: 26803520 Free PMC Article</br>2:Analysis of nedocromil sodium using ESI-QTOF. Wu ZJ, Huo JL, Lu CC, Fang DM, Wang JH.J Mass Spectrom. 2012 Jul;47(7):811-5. doi: 10.1002/jms.3024. No abstract available. PMID: 22791247 </br>3:G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium. Yang Y, Lu JY, Wu X, Summer S, Whoriskey J, Saris C, Reagan JD.Pharmacology. 2010;86(1):1-5. doi: 10.1159/000314164. Epub 2010 Jun 19. PMID: 20559017 </br>4:Benefits of budesonide or nedocromil for mild to moderate asthma in children were not sustained after discontinuation. Mellis C.Evid Based Med. 2009 Dec;14(6):175. doi: 10.1136/ebm.14.6.175. No abstract available. PMID: 19949177 </br>5:Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. Strunk RC, Sternberg AL, Szefler SJ, Zeiger RS, Bender B, Tonascia J; Childhood Asthma Management Program (CAMP) Research Group..J Pediatr. 2009 May;154(5):682-7. doi: 10.1016/j.jpeds.2008.11.036. Epub 2009 Jan 23. PMID: 19167726 Free PMC Article</br>6:The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study. Rasti M, Parvaresh E, Tavajoh S, Talaei M.Int J Surg. 2007 Dec;5(6):384-7. Epub 2007 May 10. PMID: 17569604 Free Article</br>7:AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. Bruce CT, Zhao D, Yates DH, Thomas PS.Eur J Clin Invest. 2006 Dec;36(12):899-905. PMID: 17087785 </br>8:Protective effects of nedocromil sodium and sodium cromoglycate on gastroduodenal ulcers: a comparative study in rats. Tariq M, Moutaery MA, Elfaki I, Arshaduddin M, Khan HA.Inflammopharmacology. 2006 Aug;14(3-4):163-9. PMID: 16983498 </br>9:Nedocromil sodium for chronic asthma in children. Sridhar AV, McKean M.Cochrane Database Syst Rev. 2006 Jul 19;(3):CD004108. Review. PMID: 16856028 </br>10:Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. Pitsios C, Papadopoulos D, Kompoti E, Manoussakis E, Garris V, Petalas K, Tassios I, Baibas N, Kontou-Fili K, Saxoni-Papageorgiou P, Papadopoulos NG.Ann Allergy Asthma Immunol. 2006 May;96(5):673-8. PMID: 16729779 |
