For research use only. Not for therapeutic Use.
Neladenoson dalanate HCl（Cat No.:I033146）is a novel adenosine A2A receptor agonist, primarily investigated for its potential use in treating conditions like Parkinson’s disease and other neurodegenerative disorders. The compound works by selectively activating the A2A receptor, which plays a role in regulating neurotransmitter release, particularly in the basal ganglia, a brain region involved in movement control. By modulating this receptor, neladenoson dalanate HCl may help improve motor function and reduce symptoms of Parkinson’s. Clinical trials are ongoing to assess its safety, efficacy, and potential benefits in improving quality of life for patients with Parkinson’s disease.
| Catalog Number | I033146 |
| CAS Number | 1239235-25-6 |
| Synonyms | Neladenoson dalanate hydrochloride; |
| Molecular Formula | C35H35Cl2N7O4S2 |
| Purity | 98% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-[4-[2-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-3,5-dicyano-6-pyrrolidin-1-ylpyridin-4-yl]phenoxy]ethyl (2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoate;hydrochloride |
| InChI | InChI=1S/C35H34ClN7O4S2.ClH/c1-21(39)32(44)40-22(2)35(45)47-16-15-46-27-11-7-23(8-12-27)30-28(17-37)31(43-13-3-4-14-43)42-34(29(30)18-38)49-20-26-19-48-33(41-26)24-5-9-25(36)10-6-24;/h5-12,19,21-22H,3-4,13-16,20,39H2,1-2H3,(H,40,44);1H/t21-,22-;/m0./s1 |
| InChIKey | CZZKREIGVLUWPU-VROPFNGYSA-N |
| SMILES | C[C@@H](C(=O)N[C@@H](C)C(=O)OCCOC1=CC=C(C=C1)C2=C(C(=NC(=C2C#N)SCC3=CSC(=N3)C4=CC=C(C=C4)Cl)N5CCCC5)C#N)N.Cl |
| Reference | 1: Meibom D, Albrecht-Küpper B, Diedrichs N, Hübsch W, Kast R, Krämer T, Krenz U, Lerchen HG, Mittendorf J, Nell PG, Süssmeier F, Vakalopoulos A, Zimmermann K. Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A(1) Receptor Agonist for the Chronic Treatment of Heart Diseases. ChemMedChem. 2017 May 22;12(10):728-737. doi: 10.1002/cmdc.201700151. Epub 2017 May 10. PubMed PMID: 28488817. |
