For research use only. Not for therapeutic Use.
Nelivaptan(CAT: I033149) is a selective vasopressin V1b receptor antagonist that modulates the hypothalamic-pituitary-adrenal (HPA) axis by inhibiting the effects of arginine vasopressin (AVP) on the V1b receptor. This receptor is primarily involved in stress-related endocrine responses, including the regulation of adrenocorticotropic hormone (ACTH) secretion. Nelivaptan has been investigated for its potential therapeutic applications in stress-related disorders, including anxiety, depression, and Cushing’s disease, where dysregulated vasopressin signaling contributes to disease pathology. Given its role in neuroendocrine regulation and stress response, Nelivaptan is most relevant to Endocrinology Disease Research and Neurological Disease Research, particularly in studying disorders of the HPA axis.
| Catalog Number | I033149 |
| CAS Number | 439687-69-1 |
| Synonyms | (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide |
| Molecular Formula | C30H32ClN3O8S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide |
| InChI | InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1 |
| InChIKey | NJXZWIIMWNEOGJ-WEWKHQNJSA-N |
| SMILES | CN(C)C(=O)[C@@H]1C[C@H](CN1[C@]2(C3=C(C=CC(=C3)Cl)N(C2=O)S(=O)(=O)C4=C(C=C(C=C4)OC)OC)C5=CC=CC=C5OC)O |
