Nelonicline (ABT-126)

• CAT Number: I008272
• CAS Number: 1026134-63-3
• Molecular Formula: C17H19N3OS
• Molecular Weight: 313.42
• Purity: ≥95%
• Synonyms: ABT-126; ABT126; ABT 126; Nelonicline;2-(((3R,4r,5S,7s)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2-(1-azatricyclo[3.3.1.13,7]decan-4-yloxy)-5-phenyl-1,3,4-thiadiazole
• InChI: InChI=1S/C17H19N3OS/c1-2-4-12(5-3-1)16-18-19-17(22-16)21-15-13-6-11-7-14(15)10-20(8-11)9-13/h1-5,11,13-15H,6-10H2/t11?,13-,14+,15?
• InChIKey: QZDCYUCETTWCMO-LCBVDAKKSA-N
• SMILES: C1C2CC3CN(C2)CC1C3OC4=NN=C(S4)C5=CC=CC=C5

Nelonicline (ABT-126)(CAT: I008272) is a highly selective partial agonist of the α7 nicotinic acetylcholine receptor (nAChR), widely utilized in neuroscience research. This compound is known for its potential therapeutic applications in cognitive impairment and neuropsychiatric disorders, including Alzheimer’s disease and schizophrenia. By modulating α7 nAChR activity, Nelonicline enhances cholinergic signaling, supporting studies on synaptic plasticity, memory, and neuroprotection. Its high specificity and favorable pharmacokinetic profile make it ideal for in vitro and in vivo research. Nelonicline (ABT-126) is a valuable tool for advancing therapeutic development targeting α7 nAChR in cognitive and neurodegenerative conditions.