For research use only. Not for therapeutic Use.
Nelonica (Cat No.:I008272), also known as ABT-126, is an Alpha7 nicotinic acetylcholine receptor agonist and a nicotinic acetylcholine receptor agonist. Nelonica has potential therapeutic effects in Alzheimer’s disease.
| Catalog Number | I008272 |
| CAS Number | 1026134-63-3 |
| Synonyms | ABT-126; ABT126; ABT 126; Nelonicline;2-(((3R,4r,5S,7s)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole |
| Molecular Formula | C17H19N3OS |
| Purity | ≥95% |
| Target | α7 nicotinic receptor agonist |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C17H19N3OS/c1-2-4-12(5-3-1)16-18-19-17(22-16)21-15-13-6-11-7-14(15)10-20(8-11)9-13/h1-5,11,13-15H,6-10H2/t11?,13-,14+,15? |
| InChIKey | QZDCYUCETTWCMO-LCBVDAKKSA-N |
| SMILES | C1C2CC3CN(C2)CC1C3OC4=NN=C(S4)C5=CC=CC=C5 |
| Reference | </br>1: Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik M. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord. 2015 Nov 17. doi: 10.1002/mds.26453. [Epub ahead of print] Review. PubMed PMID: 26573698.</br>2:Hashimoto K. Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker. Curr Pharm Des. 2015;21(26):3797-806. PubMed PMID: 26044974. |
