Nemadectin

• CAT Number: M010791
• CAS Number: 102130-84-7
• Molecular Formula: C36H52O8
• Molecular Weight: 612.80
• Purity: ≥95%
• Synonyms: (6R,23S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-milbemycin B
• Target: Parasite
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• InChI: InChI=1S/C36H52O8/c1-20(2)13-24(6)32-25(7)30(37)18-35(44-32)17-28-16-27(43-35)12-11-22(4)14-21(3)9-8-10-26-19-41-33-31(38)23(5)15-29(34(39)42-28)36(26,33)40/h8-11,13,15,20-21,25,27-33,37-38,40H,12,14,16-19H2,1-7H3/b9-8+,22-11+,24-13+,26-10+/t21-,25-,27+,28-,29-,30-,31+,32+,33+,35-,36+/m0/s1
• InChIKey: YNFMRVVYUVPIAN-AQUURSMBSA-N
• SMILES: C[C@@H]\1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C[C@@H]([C@@H]([C@H](O3)/C(=C/C(C)C)/C)C)O)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C

Nemadectin（Cat No.:M010791）is a naturally occurring macrolide antibiotic produced by Streptomyces species, closely related to the avermectin family. It is widely used as a broad-spectrum antiparasitic agent in veterinary medicine, effective against gastrointestinal nematodes, ectoparasites, and other parasitic organisms in livestock and companion animals. Nemadectin works by binding to glutamate-gated chloride channels in parasites, disrupting neural and muscular activity, leading to paralysis and death. With its potent efficacy, long-lasting action, and safety in animals, nemadectin plays a vital role in parasite management, improving animal health and productivity in agriculture.

Reference

1.LL-F28249 antibiotic complex: a new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. Carter G.T. et al. J Antibiot. 1988, 41, 519.
2.Efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. Doscher M.E. et al. Vet Parasitol. 1989, 34, 255.