For research use only. Not for therapeutic Use.
<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Nemadectin (CAS 102130-84-7) is a macrocyclic lactone antibiotic that demonstrates endectocidal and nematocidal activity. Differing only by the unsaturated side-chain extending from the 6,6-spiroketal core, this antibiotic is structurally similar to milbemycins and avermectins. Nemadectin has been used as starting material for the production of the veterinary anthelmintic, moxidectin, and its derivatives have been explored for their potential antiparasitic use.</span></span></span></p>
| Catalog Number | M010791 |
| CAS Number | 102130-84-7 |
| Synonyms | (6R,23S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-milbemycin B |
| Molecular Formula | C36H52O8 |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one |
| InChI | InChI=1S/C36H52O8/c1-20(2)13-24(6)32-25(7)30(37)18-35(44-32)17-28-16-27(43-35)12-11-22(4)14-21(3)9-8-10-26-19-41-33-31(38)23(5)15-29(34(39)42-28)36(26,33)40/h8-11,13,15,20-21,25,27-33,37-38,40H,12,14,16-19H2,1-7H3/b9-8+,22-11+,24-13+,26-10+/t21-,25-,27+,28-,29-,30-,31+,32+,33+,35-,36+/m0/s1 |
| InChIKey | YNFMRVVYUVPIAN-AQUURSMBSA-N |
| SMILES | CC1CC(=CCC2CC(CC3(O2)CC(C(C(O3)C(=CC(C)C)C)C)O)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C |
| Reference | 1.LL-F28249 antibiotic complex: a new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. Carter G.T. et al. J Antibiot. 1988, 41, 519.<br /> |
| Documentation | CoA |
