Nemonoxacin malate

• CAT Number: I008275
• CAS Number: 951163-60-3
• Molecular Formula: C24H31N3O9
• Molecular Weight: 505.52
• Purity: ≥95%
• Synonyms: 7-[(3S,5S)-3-amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylic acid;2-hydroxybutanedioic acid
• InChI: InChI=1S/C20H25N3O4.C4H6O5/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26;5-2(4(8)9)1-3(6)7/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26);2,5H,1H2,(H,6,7)(H,8,9)/t11-,12-;/m0./s1
• InChIKey: YMVJINCWEIPOFL-FXMYHANSSA-N
• SMILES: CC1CC(CN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)N.C(C(C(=O)O)O)C(=O)O

Nemonoxacin malate is a novel non-fluorinated quinolone antibiotic with broad-spectrum antibacterial activity. It is effective against a wide range of Gram-positive and Gram-negative bacteria, including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. Nemonoxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and cell division. Its favorable safety profile and potency make it a promising candidate for treating respiratory tract infections, skin infections, and community-acquired pneumonia, particularly where resistance to traditional antibiotics presents a clinical challenge.