Nemorexant

• CAT Number: I048023
• CAS Number: 1505484-82-1
• Molecular Formula: C23H23ClN6O2
• Molecular Weight: 450.9
• Purity: 99%
• Synonyms: Daridorexant; ACT-541468
• Target: HCRTR
• Target Protein: O43613
• Appearance: Solid
• IC50: IC50：2 nM（Ox1 receptor） and 3 nM（Ox2 receptor）
• IUPAC Name: [(2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone
• InChI: InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1
• InChIKey: NBGABHGMJVIVBW-QHCPKHFHSA-N
• SMILES: CC1=C(C=CC2=C1N=C(N2)C3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl

Nemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively.Nemorexant (Compound example 7) is a orexin receptor antagonist with IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively.