For research use only. Not for therapeutic Use.
Nenocorilant（Cat No.:I043396）is a selective antagonist of the corticotropin-releasing factor receptor 1 (CRF1), involved in the regulation of stress response and anxiety. By blocking CRF1, Nenocorilant reduces the activation of the stress-related pathways that contribute to conditions like anxiety, depression, and certain stress-related disorders. Preclinical studies suggest it may help mitigate the physiological effects of chronic stress by preventing overactivation of the hypothalamic-pituitary-adrenal (HPA) axis. Nenocorilant holds potential as a therapeutic candidate for the treatment of mood disorders, anxiety, and related psychiatric conditions.
| CAS Number | 1496509-78-4 |
| Synonyms | [(4aR)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone |
| Molecular Formula | C26H21F4N7O3S |
| Purity | ≥95% |
| IUPAC Name | [(4aR)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone |
| InChI | InChI=1S/C26H21F4N7O3S/c1-35-32-14-23(34-35)41(39,40)36-9-7-17-11-22-16(13-33-37(22)20-4-2-19(27)3-5-20)12-25(17,15-36)24(38)21-10-18(6-8-31-21)26(28,29)30/h2-6,8,10-11,13-14H,7,9,12,15H2,1H3/t25-/m0/s1 |
| InChIKey | PZIQQHVUAHTSJN-VWLOTQADSA-N |
| SMILES | CN1N=CC(=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
