Neobavaisoflavone

• CAT Number: I003495
• CAS Number: 41060-15-5
• Molecular Formula: C20H18O4
• Molecular Weight: 322.4
• Purity: ≥95%
• Synonyms: 7-hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-1-benzopyran-4-one
• Target: Apoptosis; DNA/RNA Synthesis
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: under inert gas (nitrogen or Argon) at 2-8°C
• IC50: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]
• IUPAC Name: 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one
• InChI: InChI=1S/C20H18O4/c1-12(2)3-4-14-9-13(5-8-18(14)22)17-11-24-19-10-15(21)6-7-16(19)20(17)23/h3,5-11,21-22H,4H2,1-2H3
• InChIKey: OBGPEBYHGIUFBN-UHFFFAOYSA-N
• SMILES: CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C

Neobavaisoflavone（Cat No.:I003495） is a flavonoid compound that is derived from the seeds of Psoralea corylifolia. It possesses various beneficial effects, including anti-inflammatory, anticancer, and antioxidant properties. Neobavaisoflavone can inhibit DNA polymerase at moderate to high concentrations and also exhibits inhibitory effects on platelet aggregation. These properties make it a potentially valuable compound in the development of therapeutic agents for conditions related to inflammation, cancer, oxidative stress, and platelet dysfunction.

Reference

[1]. Kim YJ, et al. Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells. Life Sci. 2014 Jan 30;95(2):101-7.
[2]. Kuete V, Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells. Phytomedicine. 2014 Apr 15;21(5):682-8.
[3]. Ming-Jaw Don, et al. Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine Volume 19, Issue 6, 15 April 2012, Pages 551–561