For research use only. Not for therapeutic Use.
Neoline (Bullatine B)) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC)，Improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain.
Neoline (1 μM) drastically decreases Nav1.7 VGSC current induced by depolarizationin HEK293 cells, with IC50 of 25.8 nM[2].
Neoline (10 mg/kg/day; sc; 10 days) alleviates oxaliplatin-induced peripheral neuropathy. Neoline inhibits paclitaxel- or partial sciatic nerve injury-induced allodynia in mice model[1].Neoline (1-10 mg/kg; sc; single dose) shows antinociceptive effect and significantly increases the mechanical nociceptive threshold in diabetic mices[2].
| Catalog Number | R035332 |
| CAS Number | 466-26-2 |
| Synonyms | (2R,3R,4S,5S,6S,8R,13S,16S,17R,18R)-11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8,16-triol |
| Molecular Formula | C24H39NO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H39NO6/c1-5-25-10-22(11-29-2)7-6-15(26)24-13-8-12-14(30-3)9-23(28,16(13)18(12)27)17(21(24)25)19(31-4)20(22)24/h12-21,26-28H,5-11H2,1-4H3/t12-,13-,14+,15+,16-,17?,18+,19+,20-,21?,22+,23-,24?/m1/s1 |
| InChIKey | XRARAKHBJHWUHW-XPGJPNGISA-N |
| SMILES | CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6CC4C5C6O)OC)O)OC)O)COC |
| Reference | [1]. Tanimura Y, et al. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.J Ethnopharmacol. 2019 Sep 15;241:111859. [2]. Nakatani Y, Negoro K, Yamauchi M, et al. Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. J Ethnopharmacol. 2020;259:112963. |
