Neophytadiene

• CAT Number: R008999
• CAS Number: 504-96-1
• Molecular Formula: C20H38
• Molecular Weight: 278.52
• Purity: ≥95%
• Synonyms: 7,11,15-trimethyl-3-methylidenehexadec-1-ene
• InChI: InChI=1S/C20H38/c1-7-18(4)12-9-14-20(6)16-10-15-19(5)13-8-11-17(2)3/h7,17,19-20H,1,4,8-16H2,2-3,5-6H3
• InChIKey: NIDGCIPAMWNKOA-UHFFFAOYSA-N
• SMILES: CC(C)CCCC(C)CCCC(C)CCCC(=C)C=C

Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties[1].
Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 μM[1].
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulates inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells[1].
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells[1].
Neophytadiene (50 mg/kg; p.o.; daily; for 7 days) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased IL-6 and 1L-10 levels and in heart tissue[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased PGE2 mRNA expression in heart tissue[1].
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo[1].

Reference

[1]. Meenakshi Bhardwaj, et al. Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation. 2020 Jun;43(3):937-950.
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