Neostigmine

• CAT Number: I008176
• CAS Number: 59-99-4
• Molecular Formula: C12H19N2O2+
• Molecular Weight: 223.296
• Purity: ≥95%
• Synonyms: Neostigmine, Prostigmin, Vagostigmin, Polstigmine;[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
• InChI: InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
• InChIKey: ALWKGYPQUAPLQC-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C

Neostigmine is a parasympathomimetic compound that acts as a reversible acetylcholinesterase inhibitor. Given that it is a quaternary amine (unlike physostigmine, which is a tertiary amine), it penetrates the central nervous system poorly and has lower propensity to cause side effects there.