Nepsilon-acetyl-L-lysine-d8

• CAT Number: I043938
• Molecular Formula: C8H8D8N2O3
• Molecular Weight: 196.27
• Purity: ≥95%
• Synonyms: (2S)-6-acetamido-2-amino-3,3,4,4,5,5,6,6-octadeuteriohexanoic acid
• InChI: InChI=1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1/i2D2,3D2,4D2,5D2
• InChIKey: DTERQYGMUDWYAZ-IYVSXXDFSA-N
• SMILES: CC(=O)NCCCCC(C(=O)O)N

Nepsilon-acetyl-L-lysine-d8 is the deuterium labeled Nepsilon-acetyl-L-lysine. Nepsilon-Acetyl-L-lysine is a derivative of the amino acid lysine.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. H Schmidt, et al. Characterization of a novel enzyme, N6-acetyl-L-lysine: 2-oxoglutarate aminotransferase, which catalyses the second step of lysine catabolism in Candida maltosa. Antonie Van Leeuwenhoek. 1992 Nov;62(4):285-90.
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[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[3]. Schmidt H, et al. Characterization of a novel enzyme, N6-acetyl-L-lysine: 2-oxoglutarate aminotransferase, which catalyses the second step of lysine catabolism in Candida maltosa. Antonie Van Leeuwenhoek. 1992 Nov;62(4):285-90.