Nesiritide

• CAT Number: I000975
• CAS Number: 124584-08-3
• Molecular Formula: C143H244N50O42S4
• Molecular Weight: 3464.05
• Purity: ≥95%
• Synonyms: (1E,3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S)-18-((1H-imidazol-5-yl)methyl)-1-((4R,5E,8Z,10S,11Z,14Z,16S,17Z,19S,20Z,22S,23E,25S,26Z,28S,29Z,31S,32E,34S,35Z,37S,38E,40S,41Z,43S,44Z,47Z,49S,50Z,52R)-52-((Z)-((1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z,16Z,18S,19Z)-1
• Target: Peptide and Derivatives
• Solubility: H2O
• Storage: Store at -20C

Nesiritide is a endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1).In vitro: BNP 1-32 (10(-6) mol/L) activats cGMP. BNP significantly (P<0.01) inhibited de novo collagen synthesis as assessed by [3H]proline incorporation, whereas zymographic MMP-2 (gelatinase) abundance was significantly (P<0.05) stimulated by BNP between 10(-7) and 10(-6) mol/L. Decreases de novo collagen synthesis and increases MMP gene expression in vitro.In vivo: inhibits the sympathetic and renin-angiotensin-aldosterone systems.

Reference

[1]. Heublein DM et al. Immunoreactivity and guanosine 3/’,5/’-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide. Hypertension. 2007 May;49(5):1114-9.
[2]. Tsuruda T et al. Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ Res. 2002 Dec 13;91(12):1127-34.
[3]. Wellard J et al. Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3/’,5/’-cyclic monophosphate in ependymal cells ex vivo. Neurosci Lett. 2006 Jan 16;392(3):187-92.