Netilmicin sulfate

For research use only. Not for therapeutic Use.

  • CAT Number: I004106
  • CAS Number: 56391-57-2
  • Molecular Formula: C21H41N5O7.2.5H2O4S
  • Molecular Weight: 1441.55
  • Purity: ≥95%
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Netilmicin Sulfate(Cat No.:I004106)is a semisynthetic aminoglycoside antibiotic effective against a broad spectrum of Gram-negative and some Gram-positive bacteria. It functions by binding to the bacterial 30S ribosomal subunit, inhibiting protein synthesis and causing cell death. Netilmicin is commonly used for severe infections, including urinary tract infections, respiratory infections, and septicemia, especially in cases involving multidrug-resistant bacteria. Its improved efficacy and reduced toxicity compared to other aminoglycosides make it a preferred choice in critical care. Netilmicin is typically administered via injection in hospital settings for rapid action.


Catalog Number I004106
CAS Number 56391-57-2
Molecular Formula C21H41N5O7.2.5H2O4S
Purity ≥95%
Solubility H2O: 40 mg/mL
Storage 3 years -20℃ powder
IUPAC Name (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
InChI InChI=1S/2C21H41N5O7.5H2O4S/c2*1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20;5*1-5(2,3)4/h2*5,11-20,25-29H,4,6-9,22-24H2,1-3H3;5*(H2,1,2,3,4)/t2*11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+;;;;;/m11...../s1
InChIKey AGFWIZQEWFGATK-UNZHCMSXSA-N
SMILES CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@@](CO2)(C)O)NC)O)O)O[C@@H]3[C@@H](CC=C(O3)CN)N)N.CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@@](CO2)(C)O)NC)O)O)O[C@@H]3[C@@H](CC=C(O3)CN)N)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
Reference

<p style=/line-height:25px/>
<br>[1]. Campoli-Richards DM, et al. Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1989 Nov;38(5):703-56.
<br>[2]. Adams E, et al. Determination of netilmicin sulfate by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 1998 Jul 3;812(1-2):151-7.
<br>[3]. Ciftci M, et al. Effects of some drugs on rat erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study. Pol J Pharmacol. 2002 May-Jun;54(3):275-80.
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