For research use only. Not for therapeutic Use.
Monohydroxy Netupitant(CAT: I005428) is a primary active metabolite of Netupitant, a selective neurokinin-1 (NK₁) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting (CINV). This metabolite retains significant affinity for NK₁ receptors, contributing to the prolonged antiemetic effect of Netupitant by blocking the action of substance P, a key neurotransmitter involved in nausea and vomiting pathways. Monohydroxy Netupitant is of interest in pharmacokinetic and metabolism research to understand its role in the drug’s efficacy, safety profile, and duration of action, supporting the development of improved therapies for managing CINV and related conditions.
| CAS Number | 910808-12-7 |
| Molecular Formula | C30H32F6N4O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Desiccate at -20C |
| IUPAC Name | 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-[2-(hydroxymethyl)phenyl]-6-(4-methylpiperazin-1-yl)pyridin-3-yl]-N,2-dimethylpropanamide |
| InChI | InChI=1S/C30H32F6N4O2/c1-28(2,20-13-21(29(31,32)33)15-22(14-20)30(34,35)36)27(42)39(4)25-17-37-26(40-11-9-38(3)10-12-40)16-24(25)23-8-6-5-7-19(23)18-41/h5-8,13-17,41H,9-12,18H2,1-4H3 |
| InChIKey | CUGOZHKFGSQBGD-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C(=O)N(C)C2=CN=C(C=C2C3=CC=CC=C3CO)N4CCN(CC4)C |
