For research use only. Not for therapeutic Use.
Neurodazine is a neurogenic inducer, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways.[1][2].
Neurodazine (5 μM; 1-10 d) treatment induces the expression of neuron-specific markers in P19 cells[1].
Neurodazine selectively suppresses astrocyte differentiation of P19 cells[1].
| Catalog Number | I010800 |
| CAS Number | 937807-66-4 |
| Synonyms | 2-[5-(3-chlorophenyl)furan-2-yl]-4,5-bis(4-methoxyphenyl)-1H-imidazole |
| Molecular Formula | C27H21ClN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30) |
| InChIKey | FEEOFPAEDSMOTO-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(O3)C4=CC(=CC=C4)Cl)C5=CC=C(C=C5)OC |
| Reference | [1]. Kim GH, et al. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4. [2]. Halder D, et al. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37. |
