Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
| Catalog Number | I005486 |
| CAS Number | 92169-45-4 |
| Synonyms | (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
| Molecular Formula | C38H63N7O8 |
| Purity | % |
| InChI | InChI=1S/C38H63N7O8/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53)/t23-,24-,27-,28-,29-,30-,31-,32-/m0/s1 |
| InChIKey | RZMLVIHXZGQADB-YLUGYNJDSA-N |
| SMILES | CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(C(C)CC)NC(=O)C(CCCCN)N |
| Reference | [1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44. |
