For research use only. Not for therapeutic Use.
Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells[1].
Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects[1].
Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker)[1].
Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2[1].
Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells[1].
Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner[1].
| Catalog Number | I005293 |
| CAS Number | 880090-88-0 |
| Synonyms | ethyl 4-[methyl-(2-phenyl-1,3-thiazol-4-yl)amino]benzoate |
| Molecular Formula | C19H18N2O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H18N2O2S/c1-3-23-19(22)15-9-11-16(12-10-15)21(2)17-13-24-18(20-17)14-7-5-4-6-8-14/h4-13H,3H2,1-2H3 |
| InChIKey | MGKYEWWFHSESJN-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC=C(C=C1)N(C)C2=CSC(=N2)C3=CC=CC=C3 |
| Reference | [1]. Warashina M, et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16;45(4):591-3. |
