Nevirapine

• CAT Number: A000432
• CAS Number: 129618-40-2
• Molecular Formula: C15H14N4O
• Molecular Weight: 266.3
• Purity: ≥95%
• Synonyms: 129618-40-2; Viramune; BI-RG-587; Viramune XR; BIRG 0587
• Target: Reverse Transcriptase
• Solubility: >13.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• InChIKey: NQDJXKOVJZTUJA-UHFFFAOYSA-N
• SMILES: CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. As with other antiretroviral drugs, HIV rapidly develops resistance if nevirapine is used alone, so recommended therapy consists of combinations of three or more antiretrovirals. Nevirapine in triple combination therapy has been shown to suppress viral load effectively when used as initial antiretroviral therapy (i.e., in antiretroviral-naive patients).

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