For research use only. Not for therapeutic Use.
Nexinhib20(CAT: I033224) is a small-molecule inhibitor that selectively targets neutrophil exocytosis by disrupting the interaction between Rab27a and its effector JFC1 (Slp1). This mechanism prevents the release of inflammatory mediators from neutrophil granules without affecting other critical neutrophil functions like chemotaxis or phagocytosis. Nexinhib20 is widely used in inflammation and immunology research to study the regulation of neutrophil-driven immune responses and the development of targeted anti-inflammatory therapies. By modulating specific intracellular trafficking pathways, Nexinhib20 offers a novel approach to controlling excessive inflammation while preserving host defense mechanisms.
| CAS Number | 331949-35-0 |
| Synonyms | (Z)-4,4-dimethyl-1-(3-nitrophenyl)-2-(1,2,4-triazol-1-yl)pent-1-en-3-one |
| Molecular Formula | C15H16N4O3 |
| Purity | ≥95% |
| IUPAC Name | (Z)-4,4-dimethyl-1-(3-nitrophenyl)-2-(1,2,4-triazol-1-yl)pent-1-en-3-one |
| InChI | InChI=1S/C15H16N4O3/c1-15(2,3)14(20)13(18-10-16-9-17-18)8-11-5-4-6-12(7-11)19(21)22/h4-10H,1-3H3/b13-8- |
| InChIKey | VKSOIYNNOFGGES-JYRVWZFOSA-N |
| SMILES | CC(C)(C)C(=O)C(=CC1=CC(=CC=C1)[N+](=O)[O-])N2C=NC=N2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
