For research use only. Not for therapeutic Use.
Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)[1][2].
Nexturastat A (5 g) has inhibitory for HDAC6 with IC50 values of 0.005 μM[1].
Nexturastat A (0-10 μM; 24 h) has substrate selectivity for HDAC62[1].
Nexturastat A has antiproliferative activity against B16 murine melanoma cells with IC50 values of 14.3 μM[1].
Nexturastat A (NexA) (0-40 µM; 48 h) suppresses viability and induced G1 phase arrest of human MM cells[2].
Nexturastat A (0, 30, 40 μM; 48 h) promotes apoptosis of MM cells via transcriptional activation of the p21 promoter[2].
Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2].
| Catalog Number | I001548 |
| CAS Number | 1403783-31-2 |
| Synonyms | 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide |
| Molecular Formula | C19H23N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23) |
| InChIKey | JZWXMCPARMXZQV-UHFFFAOYSA-N |
| SMILES | CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2 |
| Reference | [1]. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. [2]. Xiaoyang Sun, et al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci Rep. 2019 Mar 22;39(3):BSR20181916. |
