NF-κB Activation Inhibitor IV

• CAT Number: R027514
• CAS Number: 139141-12-1
• Molecular Formula: C15H13FO
• Molecular Weight: 228.26
• Purity: ≥95%
• IUPAC Name: 1-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
• InChI: InChI=1S/C15H13FO/c1-17-14-10-7-12(8-11-14)6-9-13-4-2-3-5-15(13)16/h2-11H,1H3/b9-6+
• SMILES: COC1=CC=C(C=C1)/C=C/C2=CC=CC=C2F

NF-κB Activation Inhibitor IV is a resveratrol analogue which potently inhibits the TNFα-induced activation of NF-κB (IC50 value of 0.15 μM) and is devoid of antioxidant activity.
KEYWORDS: NF-κB Activation Inhibitor IV | supplier | NF-κB inhibitor | NFκBAI4 | FME | CAS [139141-12-1] | [1463448-80-7] | Non Selective | NF-κB | Inhibitor | Transcription Factors

Reference

JJ Heynekamp et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J Med Chem. 2006 Nov 30;49(24):7182-9.

A Braeuning et al. The nuclear factor κB inhibitor (E)-2-fluoro-4′-methoxystilbene inhibits firefly luciferase. Biosci Rep. 2012 Dec;32(6):531-7.