For research use only. Not for therapeutic Use.
NF 340 (Cat.No:I008284) is a potent and selective antagonist of the neuropeptide Y (NPY) Y5 receptor. It has been extensively studied for its potential therapeutic applications in the treatment of obesity and metabolic disorders. NF 340 inhibits the binding of NPY to the Y5 receptor, which helps regulate appetite and energy balance. Further research is ongoing to explore its therapeutic benefits.
| Catalog Number | I008284 |
| CAS Number | 202982-98-7 |
| Synonyms | NF 340; NF-340; NF340.;tetrasodium;4-[[3-[[5-[(3,7-disulfonatonaphthalen-1-yl)carbamoyl]-2-methylphenyl]carbamoylamino]-4-methylbenzoyl]amino]naphthalene-2,6-disulfonate |
| Molecular Formula | C37H26N4Na4O15S4 |
| Purity | ≥95% |
| Target | P2Y Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20C |
| IUPAC Name | tetrasodium;4-[[3-[[5-[(3,7-disulfonatonaphthalen-1-yl)carbamoyl]-2-methylphenyl]carbamoylamino]-4-methylbenzoyl]amino]naphthalene-2,6-disulfonate |
| InChI | InChI=1S/C37H30N4O15S4.4Na/c1-19-3-5-23(35(42)38-33-17-27(59(51,52)53)11-21-7-9-25(15-29(21)33)57(45,46)47)13-31(19)40-37(44)41-32-14-24(6-4-20(32)2)36(43)39-34-18-28(60(54,55)56)12-22-8-10-26(16-30(22)34)58(48,49)50;;;;/h3-18H,1-2H3,(H,38,42)(H,39,43)(H2,40,41,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56);;;;/q;4*+1/p-4 |
| InChIKey | SJMHXBFWMZYDBY-UHFFFAOYSA-J |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=C3C=C(C=CC3=CC(=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)NC4=C(C=CC(=C4)C(=O)NC5=C6C=C(C=CC6=CC(=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+] |
| Reference | </br>1:MicroRNA-340 Induces Apoptosis and Inhibits Metastasis of Ovarian Cancer Cells by Inactivation of NF-x03BA;B1. Li P, Sun Y, Liu Q.Cell Physiol Biochem. 2016;38(5):1915-27. doi: 10.1159/000445553. Epub 2016 May 9. PMID: 27160777 Free Article</br>2:miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway. Shi L, Chen ZG, Wu LL, Zheng JJ, Yang JR, Chen XF, Chen ZQ, Liu CL, Chi SY, Zheng JY, Huang HX, Lin XY, Zheng F.Asian Pac J Cancer Prev. 2014;15(23):10439-44. PMID: 25556489 Free Article</br>3:UVA-340 as energy source, mimicking natural sunlight, activates the transcription factor AP-1 in cultured fibroblasts: evidence for involvement of protein kinase-C. Nakano H, Gasparro FP, Uitto J.Photochem Photobiol. 2001 Aug;74(2):274-82. PMID: 11547566 |
