NFATc1-IN-1

• CAT Number: I043369
• CAS Number: 1912422-56-0
• Molecular Formula: C13H8F2INO2
• Molecular Weight: 375.11
• Purity: ≥95%
• Synonyms: 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxybenzamide
• InChI: InChI=1S/C13H8F2INO2/c14-7-1-4-12(18)9(5-7)13(19)17-11-3-2-8(16)6-10(11)15/h1-6,18H,(H,17,19)
• InChIKey: IGRCFOGPIJEESA-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1F)C(=O)NC2=C(C=C(C=C2)I)F)O

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research[1].
NFATc1-IN-1 (compound A04) (0-2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption[1].
NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1[1].

Reference

[1]. Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 Jul 19;117:70-84.
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