For research use only. Not for therapeutic Use.
NG-25 HCl (Cat No.: I033234) is an investigational compound being studied for its potential therapeutic applications in the treatment of neurological disorders, particularly those involving neuroinflammation and cognitive decline. It is believed to work by modulating specific signaling pathways involved in neuronal function and inflammation. Preclinical research suggests NG-25 HCl may offer neuroprotective effects, potentially helping to manage conditions like Alzheimer’s disease or other neurodegenerative disorders. Ongoing clinical studies aim to assess its safety, efficacy, and overall therapeutic potential for treating cognitive and neuroinflammatory diseases.
| CAS Number | 2108554-00-1 |
| Synonyms | NG-25 HCl; NG-25 Hydrochloride; NG-25 trihydrochloride; NG-25; NG25; NG 25; |
| Molecular Formula | C29H33Cl3F3N5O2 |
| Purity | 98% |
| Target | MAP3K |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide, trihydrochloride. |
| InChI | InChI=1S/C29H30F3N5O2.3ClH/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27;;;/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38);3*1H |
| InChIKey | QOIOJVPRHIAONM-UHFFFAOYSA-N |
| SMILES | [H]Cl.[H]Cl.[H]Cl.O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C(NC=C5)=NC=C4)=C3 |
| Reference | 1. Tan, L., Nomanbhoy, T., Gurbani, D., et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J. Med. Chem. 58(1), 183-196 (2015). |
