For research use only. Not for therapeutic Use.
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1].
NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis[1].
NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects[1].
| Catalog Number | I041977 |
| CAS Number | 2598242-66-9 |
| Synonyms | propan-2-yl 6-(4-ethoxyphenyl)-4-methoxypyridine-2-carboxylate |
| Molecular Formula | C18H21NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3 |
| InChIKey | VYEIBLWRGBQRPI-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=C(C=C1)C2=NC(=CC(=C2)OC)C(=O)OC(C)C |
| Reference | [1]. Gernot F Grabner, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250. |
