For research use only. Not for therapeutic Use.
NGI-1（Cat No.:I011968）is a small-molecule inhibitor targeting oligosaccharyltransferase (OST), an enzyme complex essential for protein N-glycosylation, which is critical for protein folding and stability in cells. By inhibiting OST, NGI-1 disrupts N-glycosylation, affecting the function of glycoproteins involved in cell signaling, immune response, and viral infection processes. NGI-1 has shown potential in cancer research for impairing glycoprotein-driven signaling pathways in tumor cells, leading to decreased cell proliferation and viability. Its antiviral activity is also under investigation, as it may prevent viral proteins from properly folding, thereby inhibiting viral replication.
| Catalog Number | I011968 |
| CAS Number | 790702-57-7 |
| Synonyms | NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414;5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide |
| Molecular Formula | C17H22N4O3S2 |
| Purity | ≥95% |
| Target | Virus Protease |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide |
| InChI | InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22) |
| InChIKey | QPKGRLIYJGBKJL-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(S1)NC(=O)C2=C(C=CC(=C2)S(=O)(=O)N(C)C)N3CCCC3 |
| Reference | </br>1: Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194. Epub 2016 Oct 3. PubMed PMID: 27694802; PubMed Central PMCID: PMC5393272.</br></br> |
