NH-bis-PEG4

For research use only. Not for therapeutic Use.

  • CAT Number: I015916
  • CAS Number: 63721-14-2
  • Molecular Formula: C16H35NO8
  • Molecular Weight: 369.45
  • Purity: ≥95%
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NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


Catalog Number I015916
CAS Number 63721-14-2
Synonyms

2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethylamino]ethoxy]ethoxy]ethoxy]ethanol

Molecular Formula C16H35NO8
Purity ≥95%
InChI InChI=1S/C16H35NO8/c18-3-7-22-11-15-24-13-9-20-5-1-17-2-6-21-10-14-25-16-12-23-8-4-19/h17-19H,1-16H2
InChIKey MTDAOFBRUZCGHZ-UHFFFAOYSA-N
SMILES C(COCCOCCOCCO)NCCOCCOCCOCCO
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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