NH2-PEG2-C6-Cl

• CAT Number: I044719
• CAS Number: 744203-60-9
• Molecular Formula: C10H22ClNO2
• Molecular Weight: 223.74
• Purity: ≥95%
• Synonyms: 2-[2-(6-chlorohexoxy)ethoxy]ethanamine
• InChI: InChI=1S/C10H22ClNO2/c11-5-3-1-2-4-7-13-9-10-14-8-6-12/h1-10,12H2
• InChIKey: ABAUJBZQEHFSKW-UHFFFAOYSA-N
• SMILES: C(CCCCl)CCOCCOCCN

NH2-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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