For research use only. Not for therapeutic Use.
NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044625 |
| CAS Number | 1261350-60-0 |
| Synonyms | 2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethanamine |
| Molecular Formula | C12H26ClNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H26ClNO3/c13-5-3-1-2-4-7-15-9-11-17-12-10-16-8-6-14/h1-12,14H2 |
| InChIKey | RWQXYKFBNPVKHW-UHFFFAOYSA-N |
| SMILES | C(CCCCl)CCOCCOCCOCCN |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
