For research use only. Not for therapeutic Use.
NH2-UAMC1110 TFA(CAT: I040998) is a potent and selective inhibitor targeting deubiquitinating enzymes (DUBs), making it a valuable tool for cancer, inflammation, and neurodegenerative disease research. This compound features an amine-functionalized (NH2) derivative of UAMC1110, enhancing its biochemical properties for enzyme binding and cellular uptake. The trifluoroacetate (TFA) salt form ensures stability and solubility for in vitro and in vivo studies. NH2-UAMC1110 TFA is ideal for exploring ubiquitin-proteasome system (UPS) mechanisms, protein degradation pathways, and novel therapeutic strategies. For research use only; not for human or clinical applications.
| Catalog Number | I040998 |
| CAS Number | 2990021-73-1 |
| Synonyms | 6-(4-aminobutoxy)-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C23H24F5N5O5 |
| Purity | ≥95% |
| IUPAC Name | 6-(4-aminobutoxy)-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C21H23F2N5O3.C2HF3O2/c22-21(23)10-14(11-25)28(13-21)19(29)12-27-20(30)16-5-7-26-18-4-3-15(9-17(16)18)31-8-2-1-6-24;3-2(4,5)1(6)7/h3-5,7,9,14H,1-2,6,8,10,12-13,24H2,(H,27,30);(H,6,7)/t14-;/m0./s1 |
| InChIKey | CCMVWHIZASXFHY-UQKRIMTDSA-N |
| SMILES | C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OCCCCN)C#N.C(=O)(C(F)(F)F)O |
