For research use only. Not for therapeutic Use.
NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1][2].
| Catalog Number | I040998 |
| CAS Number | 2990021-73-1 |
| Synonyms | 6-(4-aminobutoxy)-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C23H24F5N5O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H23F2N5O3.C2HF3O2/c22-21(23)10-14(11-25)28(13-21)19(29)12-27-20(30)16-5-7-26-18-4-3-15(9-17(16)18)31-8-2-1-6-24;3-2(4,5)1(6)7/h3-5,7,9,14H,1-2,6,8,10,12-13,24H2,(H,27,30);(H,6,7)/t14-;/m0./s1 |
| InChIKey | CCMVWHIZASXFHY-UQKRIMTDSA-N |
| SMILES | C1C(N(CC1(F)F)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OCCCCN)C#N.C(=O)(C(F)(F)F)O |
| Reference | [1]. Euy Sung Moon, et al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. [2]. Kristina Hoot Young, et al. Preclinical combination of radiation and fibroblast activation protein inhibition in pancreatic cancer. Journal of Clinical Oncology. 2016, 34 (15). |
